Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A molecular determinant for the establishment of sister chromatid cohesion.

Science (New York, N.Y.) - 25 Jul 2008

Unal Elçin, Heidinger-Pauli Jill M, Kim Woong, Guacci Vincent, Onn Itay, Gygi Steven P, Koshland Douglas E

Abstract excerpt

Chromosome segregation, transcriptional regulation, and repair of DNA double-strand breaks require the cohesin protein complex. Cohesin holds the replicated chromosomes (sister chromatids) together to mediate sister chromatid cohesion. The mechanism of how cohesion is established is unknown. We found that in budding yeast, the head domain of the Smc3p subunit of cohesin is acetylated by the Eco1p...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to Chondroitin Sulfate Proteoglycans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatids

Share to Chromosomal Proteins, Non-Histone

Share to Chromosomes, Fungal

Share to G1 Phase

Share to G2 Phase

Share to S Phase

Source

Identifiers

PMID: 18653894
DOI: 10.1126/science.1157880

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A molecular determinant for the establishment of sister chromatid cohesion.PMID 18653894Read ↗

Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion.Semantic proximity Read ↗

A novel mechanism for the establishment of sister chromatid cohesion by the ECO1 acetyltransferase.Semantic proximity Read ↗

Cohesin-independent segregation of sister chromatids in budding yeast.Semantic proximity Read ↗

DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7).Semantic proximity Read ↗

Impairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function.Semantic proximity Read ↗

Genetic evidence that the acetylation of the Smc3p subunit of cohesin modulates its ATP-bound state to promote cohesion establishment in Saccharomyces cerevisiae.Semantic proximity Read ↗

A multi-step pathway for the establishment of sister chromatid cohesion.Semantic proximity Read ↗

Pds5 promotes and protects cohesin acetylation.Semantic proximity Read ↗

Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity.Semantic proximity Read ↗

Sister Chromatid Cohesion Establishment Factor ESCO1 Operates by Substrate-Assisted Catalysis.Semantic proximity Read ↗

Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase.Semantic proximity Read ↗

Pds5 regulates sister chromatid cohesion by controlling cohesin ATPase activity through the Eco1-Smc3 acetylation pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.