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Article

The cohesin acetyltransferase Eco1 coordinates rDNA replication and transcription.

EMBO reports - 1 May 2014

Lu Shuai, Lee Kenneth K, Harris Bethany, Xiong Bo, Bose Tania, Saraf Anita, Hattem Gaye, Florens Laurence, Seidel Chris, Gerton Jennifer L

Abstract excerpt

Eco1 is the acetyltransferase that establishes sister-chromatid cohesion during DNA replication. A budding yeast strain with an eco1 mutation that genocopies Roberts syndrome has reduced ribosomal DNA (rDNA) transcription and a transcriptional signature of starvation. We show that deleting FOB1--a gene that encodes a replication fork-blocking protein specific for the rDNA region--rescues rRNA production and...

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Share to Acetyltransferases
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohesins

Share to DNA, Fungal

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Share to DNA, Ribosomal

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Share to RNA, Ribosomal

Source

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Identifiers

PMID: 24631914
DOI: 10.1002/embr.201337974
PMCID: PMC4210108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The cohesin acetyltransferase Eco1 coordinates rDNA replication and transcription.PMID 24631914Read ↗

Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion.Semantic proximity Read ↗

Eco1 is important for DNA damage repair in S. cerevisiae.Semantic proximity Read ↗

Cohesion promotes nucleolar structure and function.Semantic proximity Read ↗

DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7).Semantic proximity Read ↗

Functional control of Eco1 through the MCM complex in sister chromatid cohesion.Semantic proximity Read ↗

G1-Cyclin2 (Cln2) promotes chromosome hypercondensation in <i>eco1/ctf7 rad61</i> null cells during hyperthermic stress in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

PCNA promotes context-specific sister chromatid cohesion establishment separate from that of chromatin condensation.Semantic proximity Read ↗

Fdo1, Fkh1, Fkh2 and the Swi6-Mbp1 MBF complex regulate Mcd1 levels to impact eco1 rad61 cell growth in Saccharomyces cerevisiaeSemantic proximity Read ↗

Two putative acetyltransferases, san and deco, are required for establishing sister chromatid cohesion in Drosophila.Semantic proximity Read ↗

Cohesin proteins promote ribosomal RNA production and protein translation in yeast and human cells.Semantic proximity Read ↗

The acetyltransferase Eco1 elicits cohesin dimerization during S phaseSemantic proximity Read ↗

Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase.Semantic proximity Read ↗

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