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Article

A novel mechanism for the establishment of sister chromatid cohesion by the ECO1 acetyltransferase.

Molecular biology of the cell - 1 Jan 2015

Guacci Vincent, Stricklin Jeremiah, Bloom Michelle S, Guō Xuánzōng, Bhatter Meghna, Koshland Douglas

Abstract excerpt

Cohesin complex mediates cohesion between sister chromatids, which promotes high-fidelity chromosome segregation. Eco1p acetylates the cohesin subunit Smc3p during S phase to establish cohesion. The current model posits that this Eco1p-mediated acetylation promotes establishment by abrogating the ability of Wpl1p to destabilize cohesin binding to chromosomes. Here we present data from budding yeast that is...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomal Proteins, Non-Histone

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Share to Chromosomes, Fungal

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Source

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Identifiers

PMID: 25378582
DOI: 10.1091/mbc.E14-08-1268
PMCID: PMC4279223

Genes

SMC3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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