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Article

Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis.

The Journal of biological chemistry - 5 Sept 2008

Hayakawa Fumihiko, Abe Akihiro, Kitabayashi Issay, Pandolfi Pier Paolo, Naoe Tomoki

Abstract excerpt

PML is a potent tumor suppressor and proapoptotic factor and is functionally regulated by post-translational modifications such as phosphorylation, sumoylation, and ubiquitination. Histone deacetylase (HDAC) inhibitors are a promising class of targeted anticancer agents and induce apoptosis in cancer cells by largely unknown mechanisms. We report here a novel post-transcriptional modification, acetylation, of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18621739
DOI: 10.1074/jbc.M802217200
PMCID: PMC3259823

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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