Article
Impairment of p53 acetylation, stability and function by an oncogenic transcription factor.
The EMBO journal - 10 Mar 2004
Insinga Alessandra, Monestiroli Silvia, Ronzoni Simona, Carbone Roberta, Pearson Mark, Pruneri Giancarlo, Viale Giuseppe, Appella Ettore, Pelicci PierGiuseppe, Minucci Saverio
Abstract excerpt
Mutations of p53 are remarkably rare in acute promyelocytic leukemias (APLs). Here, we demonstrate that the APL-associated fusion proteins PML-RAR and PLZF-RAR directly inhibit p53, allowing leukemic blasts to evade p53-dependent cancer surveillance pathways. PML-RAR causes deacetylation and degradation of p53, resulting in repression of p53 transcriptional activity, and protection from p53-dependent responses to...
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