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Article

PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development

1 Aug 2016

Abstract excerpt

The precise molecular mechanisms that coordinate apoptosis and autophagy in cancer remain to be determined. Here, we provide evidence that the tumor suppressor promyelocytic leukemia protein (PML) controls autophagosome formation at mitochondria-associated membranes (MAMs) and, thus, autophagy induction. Our in vitro and in vivo results demonstrate how PML functions as a repressor of autophagy. PML loss promotes...

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PMID: 27545895
DOI: 10.1016/j.celrep.2016.07.082

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