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The function, regulation and therapeutic implications of the tumor suppressor protein, PML

4 Nov 2015

Abstract excerpt

The tumor suppressor protein, promyelocytic leukemia protein (PML), was originally identified in acute promyelocytic leukemia due to a chromosomal translocation between chromosomes 15 and 17. PML is the core component of subnuclear structures called PML nuclear bodies (PML-NBs), which are disrupted in acute promyelocytic leukemia cells. PML plays important roles in cell cycle regulation, survival and apoptosis,...

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PMID: 26539288
DOI: 10.1186/s13578-015-0051-9

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