Article
The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.
Cancer research - 1 May 2012
Rabellino Andrea, Carter Brandon, Konstantinidou Georgia, Wu Shwu-Yuan, Rimessi Alessandro, Byers Lauren A, Heymach John V, Girard Luc, Chiang Cheng-Ming, Teruya-Feldstein Julie, Scaglioni Pier Paolo
Abstract excerpt
The ubiquitin-like SUMO proteins covalently modify protein substrates and regulate their functional properties. In a broad spectrum of cancers, the tumor suppressor PML undergoes ubiquitin-mediated degradation primed by CK2 phosphorylation. Here, we report that the SUMO E3-ligase inhibitor PIAS1 regulates oncogenic signaling through its ability to sumoylate PML and the PML-RARA oncoprotein of acute promyelocytic...
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