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PML: Regulation and multifaceted function beyond tumor suppression

25 Jan 2018

Abstract excerpt

Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic acid receptor alpha in acute promyelocytic leukemia patients with the (15;17) chromosomal translocation, giving rise to PML-RARα and RARα-PML fusion proteins. A body of evidence indicated that PML possesses tumor suppressing activity by regulating apoptosis, cell cycle, senescence and DNA damage responses. PML is...

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PMID: 29416846
DOI: 10.1186/s13578-018-0204-8

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