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Article

Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells.

Molecular and cellular biology - 1 Feb 2008

Reineke Erin L, Lam Minh, Liu Qing, Liu Yu, Stanya Kristopher J, Chang Kun-Sang, Means Anthony R, Kao Hung-Ying

Abstract excerpt

Promyelocytic leukemia protein (PML) is an important regulator due to its role in numerous cellular processes including apoptosis, viral infection, senescence, DNA damage repair, and cell cycle regulation. Despite the role of PML in many cellular functions, little is known about the regulation of PML itself. We show that PML stability is regulated through interaction with the peptidyl-prolyl cis-trans isomerase...

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Source

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Identifiers

PMID: 18039859
DOI: 10.1128/MCB.01848-07
PMCID: PMC2223389

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells.PMID 18039859Read ↗

Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT.Semantic proximity Read ↗

The function, regulation and therapeutic implications of the tumor suppressor protein, PMLSemantic proximity Read ↗

Targeting carcinogenesis: A role for the prolyl isomerase Pin1?Semantic proximity Read ↗

Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and SignificanceSemantic proximity Read ↗

The role of the master cancer regulator Pin1 in the development and treatment of cancerSemantic proximity Read ↗

SENP1 deSUMOylates and Regulates Pin1 Protein Activity and Cellular FunctionSemantic proximity Read ↗

Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function.Semantic proximity Read ↗

PIN1 and CDK1 cooperatively govern pVHL stability and suppressive functionsSemantic proximity Read ↗

The implication of the SUMOylation pathway in breast cancer pathogenesis and treatmentSemantic proximity Read ↗

Prevalent overexpression of prolyl isomerase Pin1 in human cancers.Semantic proximity Read ↗

Pin1 modulates ERα levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradationSemantic proximity Read ↗

PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.Semantic proximity Read ↗

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