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Article

Epigenetic Targeting of Autophagy via HDAC Inhibition in Tumor Cells: Role of p53

8 Dec 2018

Abstract excerpt

Tumor development and progression is the consequence of genetic as well as epigenetic alterations of the cell. As part of the epigenetic regulatory system, histone acetyltransferases (HATs) and deacetylases (HDACs) drive the modification of histone as well as non-histone proteins. Derailed acetylation-mediated gene expression in cancer due to a delicate imbalance in HDAC expression can be reversed by histone...

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Share to Autophagy in Disease and Therapy
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PMID: 30544838
DOI: 10.3390/ijms19123952

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