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Article

PML nuclear bodies: regulation, function and therapeutic perspectives

20 Aug 2014

Abstract excerpt

PML nuclear bodies (NBs) were first described by electron microscopy and rediscovered through their treatment-reversible disruption in a rare leukaemia. They recruit multiple partner proteins and now emerge as interferon- and oxidative stress-responsive sumoylation factories. NBs mediate interferon-induced viral restriction, enhance proteolysis, finely tune metabolism and enforce stress-induced senescence. Apart...

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PMID: 25138686
DOI: 10.1002/path.4426

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