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Article

A cytoplasmic PML mutant inhibits p53 function.

Cell cycle (Georgetown, Tex.) - 1 Nov 2006

Bellodi Cristian, Kindle Karin, Bernassola Francesca, Cossarizza Andrea, Dinsdale David, Melino Gerry, Heery David, Salomoni Paolo

Abstract excerpt

The promyelocytic leukaemia gene (Pml) is a tumor suppressor identified in acute promyelocytic leukaemia (APL), where it is fused to RAR alpha gene as a result of the chromosomal translocation t(15;17). Pml encodes both nuclear and cytoplasmic isoforms. While nuclear PML has been intensively investigated, cytoplasmic PML proteins are less characterized. PML nuclear isoforms (nPML) are the essential components of...

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Topics

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Share to Cytoplasm
Share to HL-60 Cells
Share to Leukemia, Promyelocytic, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Fluorescence

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Share to Promyelocytic Leukemia Protein

Share to Tumor Suppressor Protein p53

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Source

Identifiers

PMID: 17172828
DOI: 10.4161/cc.5.22.3504

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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