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Article

The PML hub: An emerging actor of leukemia therapies

10 Jun 2023

Abstract excerpt

PML assembles into nuclear domains that have attracted considerable attention from cell and cancer biologists. Upon stress, PML nuclear bodies modulate sumoylation and other post-translational modifications, providing an integrated molecular framework for the multiple roles of PML in apoptosis, senescence, or metabolism. PML is both a sensor and an effector of oxidative stress. Emerging data has demonstrated its...

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PMID: 37382966
DOI: 10.1084/jem.20221213

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