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Article

C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine.

Cancer research - 1 Jul 2008

Wilkins Julie A, Sansom Owen J

Abstract excerpt

The Adenomatous polyposis coli (Apc) gene is mutated in up to 80% of sporadic colorectal cancers. After Apc loss, there is deregulation of the Wnt signaling pathway and transactivation of T-cell factor/leukemia enhancing factor target genes such as C-Myc. This review focuses on recent data highlighting the importance of the C-Myc oncogene and its transcriptional targets in establishing all of the phenotypes...

Read the complete abstract on PubMed

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Share to Adenomatous Polyposis Coli Protein
Share to Cell Proliferation
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, APC

Share to Intestinal Mucosa

Share to Loss of Heterozygosity

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Share to Proto-Oncogene Proteins c-myc

Source

Identifiers

PMID: 18593890
DOI: 10.1158/0008-5472.CAN-07-5558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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