Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wnt signaling and colon carcinogenesis: Beyond APC

1 Jan 2011

Abstract excerpt

Activation of the Wnt signaling pathway via mutation of the adenomatous polyposis coli gene (APC) is a critical event in the development of colon cancer. For colon carcinogenesis, however, constitutive signaling through the canonical Wnt pathway is not a singular event. Here we review how canonical Wnt signaling is modulated by intracellular LEF/TCF composition and location, the action of different Wnt ligands,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Digestive system and related health
Share to Genetic factors in colorectal cancer
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21483657
DOI: 10.4103/1477-3163.78111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wnt signaling and colon carcinogenesis: Beyond APCPMID 21483657Read ↗

The canonical Wnt signalling pathway and its APC partner in colon cancer development.Semantic proximity Read ↗

Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders.Semantic proximity Read ↗

New perspectives on APC control of cell fate and proliferation in colorectal cancerSemantic proximity Read ↗

Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and MechanismsSemantic proximity Read ↗

The role of the Wnt signalling pathway in colorectal tumorigenesis.Semantic proximity Read ↗

Wnt-Independent and Wnt-Dependent Effects of APC Loss on the Chemotherapeutic ResponseSemantic proximity Read ↗

Advances of Wnt Signalling Pathway in Colorectal CancerSemantic proximity Read ↗

Colorectal cancer and genetic alterations in the Wnt pathway.Semantic proximity Read ↗

Wnt signaling in colorectal cancer: pathogenic role and therapeutic targetSemantic proximity Read ↗

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells.Semantic proximity Read ↗

Biology of the adenomatous polyposis coli tumor suppressor.Semantic proximity Read ↗

APC and its modifiers in colon cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.