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Article

Myc deletion rescues Apc deficiency in the small intestine.

Nature - 5 Apr 2007

Sansom Owen J, Meniel Valerie S, Muncan Vanesa, Phesse Toby J, Wilkins Julie A, Reed Karen R, Vass J Keith, Athineos Dimitris, Clevers Hans, Clarke Alan R

Abstract excerpt

The APC gene encodes the adenomatous polyposis coli tumour suppressor protein, germline mutation of which characterizes familial adenomatous polyposis (FAP), an autosomal intestinal cancer syndrome. Inactivation of APC is also recognized as the key early event in the development of sporadic colorectal cancers, and its loss results in constitutive activity of the beta-catenin-Tcf4 transcription complex. The...

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17377531
DOI: 10.1038/nature05674

Genes

APC
FAP
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myc deletion rescues Apc deficiency in the small intestine.PMID 17377531Read ↗

C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine.Semantic proximity Read ↗

Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine.Semantic proximity Read ↗

Identification of c-MYC as a target of the APC pathway.Semantic proximity Read ↗

Role of c-Myc in Apc mutant intestinal phenotype: case closed or time for a new beginning?Semantic proximity Read ↗

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver.Semantic proximity Read ↗

c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium.Semantic proximity Read ↗

Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferationSemantic proximity Read ↗

Exploiting APC Function as a Novel Cancer TherapySemantic proximity Read ↗

Biology of the adenomatous polyposis coli tumor suppressor.Semantic proximity Read ↗

Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation.Semantic proximity Read ↗

Studying the consequences of immediate loss of gene function in the intestine: APC.Semantic proximity Read ↗

Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisationSemantic proximity Read ↗

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