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Article

Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation.

Journal of cell science - 27 Jan 2021

Rannikmae Helena, Peel Samantha, Barry Simon, Senda Takao, de la Roche Marc

Abstract excerpt

The adenomatous polyposis coli (Apc) protein regulates diverse effector pathways essential for tissue homeostasis. Truncating oncogenic mutations in Apc removing its Wnt pathway and microtubule regulatory domains drives intestinal epithelia tumorigenesis. Exuberant cell proliferation is one well-established consequence of oncogenic Wnt pathway activity; however, the contribution of other deregulated molecular...

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Identifiers

PMID: 33335067
DOI: 10.1242/jcs.250019
PMCID: PMC7860127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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