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Article

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer.

Journal of the National Cancer Institute - 1 Aug 2017

Zhang Lu, Shay Jerry W

Abstract excerpt

Adenomatous polyposis coli (APC) is widely accepted as a tumor suppressor gene highly mutated in colorectal cancers (CRC). Mutation and inactivation of this gene is a key and early event almost uniquely observed in colorectal tumorigenesis. Alterations in the APC gene generate truncated gene products, leading to activation of the Wnt signaling pathway and deregulation of multiple other cellular processes. It has...

Topics

Adenomatous Polyposis Coli Protein
Cell Transformation, Neoplastic
Colorectal Neoplasms
Genetic Predisposition to Disease
Humans
Models, Genetic
Mutation
Tumor Suppressor Proteins
Wnt Signaling Pathway
beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28423402
DOI: 10.1093/jnci/djw332
PMCID: PMC5963831

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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