Article
Identification of c-MYC as a target of the APC pathway.
Science (New York, N.Y.) - 4 Sept 1998
He T C, Sparks A B, Rago C, Hermeking H, Zawel L, da Costa L T, Morin P J, Vogelstein B, Kinzler K W
Abstract excerpt
The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of APC cause aberrant accumulation of beta-catenin, which then binds T cell factor-4 (Tcf-4), causing increased transcriptional activation of unknown genes. Here, the c-M...
Topics
- Adenomatous Polyposis Coli Protein
- Binding Sites
- Cell Line
- Colorectal Neoplasms
- Cytoskeletal Proteins
- Gene Expression Regulation, Neoplastic
- Genes, APC
- Genes, Reporter
- Genes, myc
- HT29 Cells
- Humans
- Mutation
- Promoter Regions, Genetic
- Proto-Oncogene Proteins c-myc
- Signal Transduction
- TCF Transcription Factors
- Trans-Activators
- Transcription Factor 7-Like 2 Protein