Article

Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation

2020-06-12

Abstract excerpt

The tumour suppressor adenomatous polyposis coli (Apc) regulates diverse effector pathways essential for cellular homeostasis. Truncating mutations in Apc, leading to the loss of its Wnt pathway and microtubule regulatory domains, are oncogenic in human and murine intestinal epithelia and drive malignant transformation. Whereas uncontrolled proliferation via Wnt pathway deregulation is an unequivocal consequence o...

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Literature Corpus work: d6836aea-ffe4-52e8-b0fe-61ea43729645
DOI: 10.1101/2020.06.10.143800

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