Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine.

Abstract excerpt

The adenomatous polyposis coli (APC) gene encodes APC tumour suppressor protein, germline mutation of which causes familial adenomatous polyposis, an autosomal intestinal cancer syndrome. We have previously demonstrated that the proto-oncogene c-Myc is essential for all the phenotypes that occur after APC loss in the murine small intestine. One caveat to this study is that it was performed in the complete absence...

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