Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of c-Myc in Apc mutant intestinal phenotype: case closed or time for a new beginning?

Cancer cell - 1 May 2007

Bommer Guido T, Fearon Eric R

Abstract excerpt

Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene occurs in most colorectal cancers. The proto-oncogene c-MYC was one of the first genes linked to APC inactivation, but the in vivo significance of c-MYC's enhanced expression in intestinal cells with APC defects has been u...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to APC gene
Share to MYC gene
Share to Genes, APC

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, myc

Share to Intestinal Mucosa

Share to Mutation

Share to Phenotype

Source

Identifiers

PMID: 17482129
DOI: 10.1016/j.ccr.2007.04.015

Genes

APC
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17482129-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of c-Myc in Apc mutant intestinal phenotype: case closed or time for a new beginning?PMID 17482129Read ↗

C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine.Semantic proximity Read ↗

Myc deletion rescues Apc deficiency in the small intestine.Semantic proximity Read ↗

Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine.Semantic proximity Read ↗

Identification of c-MYC as a target of the APC pathway.Semantic proximity Read ↗

Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseasesSemantic proximity Read ↗

Inhibition of Intestinal Polyposis with Reduced Angiogenesis in ApcMin/+ Mice Due to Decreases in c-Myc ExpressionSemantic proximity Read ↗

Cancer genetics: tumor suppressor meets oncogene.Semantic proximity Read ↗

Role of c-Myc in intestinal tumorigenesis of the ApcMin/+ mouse.Semantic proximity Read ↗

Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation.Semantic proximity Read ↗

Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior.Semantic proximity Read ↗

Studying the consequences of immediate loss of gene function in the intestine: APC.Semantic proximity Read ↗

c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.