Article
Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure.
Circulation - 15 Jul 2008
O'Connor Daniel T, Zhu Gu, Rao Fangwen, Taupenot Laurent, Fung Maple M, Das Madhusudan, Mahata Sushil K, Mahata Manjula, Wang Lei, Zhang Kuixing, Greenwood Tiffany A, Shih Pei-an Betty, Cockburn Myles G, Ziegler Michael G, Stridsberg Mats, Martin Nicholas G, Whitfield John B
Abstract excerpt
BACKGROUND: Chromogranin A (CHGA) triggers catecholamine secretory granule biogenesis, and its catestatin fragment inhibits catecholamine release. We approached catestatin heritability using twin pairs, coupled with genome-wide linkage, in a series of twin and sibling pairs from 2 continents. METHODS AND RESULTS: Hypertensive patients had elevated CHGA coupled with reduction in catestatin, suggesting diminished...
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