Article
A haplotype variant of the human chromogranin A gene (CHGA) promoter increases CHGA expression and the risk for cardiometabolic disorders.
The Journal of biological chemistry - 25 Aug 2017
Subramanian Lakshmi, Khan Abrar A, Allu Prasanna K R, Kiranmayi Malapaka, Sahu Bhavani S, Sharma Saurabh, Khullar Madhu, Mullasari Ajit S, Mahapatra Nitish R
Abstract excerpt
The acidic glycoprotein chromogranin A (CHGA) is co-stored/co-secreted with catecholamines and crucial for secretory vesicle biogenesis in neuronal/neuroendocrine cells. CHGA is dysregulated in several cardiovascular diseases, but the underlying mechanisms are not well established. Here, we sought to identify common polymorphisms in the CHGA promoter and to explore the mechanistic basis of their plausible...
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