Article
The catecholamine release-inhibitory "catestatin" fragment of chromogranin a: naturally occurring human variants with different potencies for multiple chromaffin cell nicotinic cholinergic responses.
Molecular pharmacology - 1 Nov 2004
Mahata Sushil K, Mahata Manjula, Wen Gen, Wong William B, Mahapatra Nitish R, Hamilton Bruce A, O'Connor Daniel T
Abstract excerpt
The catestatin fragment of chromogranin A is an endogenous inhibitor of nicotinic cholinergic transmission, functioning in negative feedback control of catecholamine secretion. We explored naturally occurring polymorphisms in the amino acid sequence of catestatin. Three human variants were identified: Gly364Ser, Pro370Leu, and Arg374Gln. Variants were tested for ability to inhibit four nicotinic processes. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.