Article
Catecholamine storage vesicles: role of core protein genetic polymorphisms in hypertension.
Current hypertension reports - 1 Feb 2011
Zhang Kuixing, Chen Yuqing, Wen Gen, Mahata Manjula, Rao Fangwen, Fung Maple M, Vaingankar Sucheta, Biswas Nilima, Gayen Jiaur R, Friese Ryan S, Mahata Sushil K, Hamilton Bruce A, O'Connor Daniel T
Abstract excerpt
Hypertension is a complex trait with deranged autonomic control of the circulation. The sympathoadrenal system exerts minute-to-minute control over cardiac output and vascular tone. Catecholamine storage vesicles (or chromaffin granules) of the adrenal medulla contain remarkably high concentrations of chromogranins/secretogranins (or "granins"), catecholamines, neuropeptide Y, adenosine triphosphate (ATP), and...
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