Article
Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension.
Circulation - 1 May 2007
Rao Fangwen, Wen Gen, Gayen Jiaur R, Das Madhusudan, Vaingankar Sucheta M, Rana Brinda K, Mahata Manjula, Kennedy Brian P, Salem Rany M, Stridsberg Mats, Abel Kenneth, Smith Douglas W, Eskin Eleazar, Schork Nicholas J, Hamilton Bruce A, Ziegler Michael G, Mahata Sushil K, O'Connor Daniel T
Abstract excerpt
BACKGROUND: Chromogranin A, coreleased with catecholamines by exocytosis, is cleaved to the catecholamine release-inhibitory fragment catestatin. We identified a natural nonsynonymous variant of catestatin, Gly364Ser, that alters human autonomic function and blood pressure. METHODS AND RESULTS: G...
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