Article
A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population.
Endocrine journal - 1 Jan 2015
Choi Youngju, Miura Masahiro, Nakata Yoshio, Sugasawa Takehito, Nissato Sumiko, Otsuki Takeshi, Sugawara Jun, Iemitsu Motoyuki, Kawakami Yasushi, Shimano Hitoshi, Iijima Yoshimi, Tanaka Kiyoji, Kuno Shinya, Allu Prasanna K R, Mahapatra Nitish R, Maeda Seiji, Takekoshi Kazuhiro
Abstract excerpt
Chromogranin A (CHGA) is a major protein in the secretory granules of chromaffin cells. CHGA also gives rise to cardiovascular/metabolism regulatory peptides, such as catestatin (CST) and pancreastatin (PST). While CST is a potent inhibitor of catecholamine secretion, PST is a potent physiological inhibitor of glucose-induced insulin secretion. Recently, several SNPs were identified in the CST and PST domains of...
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