Article
Functional genetic variants of the catecholamine-release-inhibitory peptide catestatin in an Indian population: allele-specific effects on metabolic traits.
The Journal of biological chemistry - 21 Dec 2012
Sahu Bhavani S, Obbineni Jagan M, Sahu Giriraj, Allu Prasanna K R, Subramanian Lakshmi, Sonawane Parshuram J, Singh Pradeep K, Sasi Binu K, Senapati Sanjib, Maji Samir K, Bera Amal K, Gomathi Balashankar S, Mullasari Ajit S, Mahapatra Nitish R
Abstract excerpt
Catestatin (CST), a chromogranin A (CHGA)-derived peptide, is a potent inhibitor of catecholamine release from adrenal chromaffin cells and postganglionic sympathetic axons. We re-sequenced the CST region of CHGA in an Indian population (n = 1010) and detected two amino acid substitution variants: G364S and G367V. Synthesized CST variant peptides (viz. CST-Ser-364 and CST-Val-367) were significantly less potent...
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