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Article

Proteomic analysis yields an unexpected trans-acting point in control of the human sympathochromaffin phenotype.

Circulation. Cardiovascular genetics - 1 Aug 2011

Chiron Stéphane, Wei Zhiyun, Chen Yuqing, Zhang Kuixing, Wen Gen, Fischer Wolfgang H, Mahata Sushil K, O'Connor Daniel T

Abstract excerpt

BACKGROUND: The secretory protein chromogranin A (CHGA) plays a necessary role in formation of catecholamine storage vesicles and gives rise to a catecholamine release-inhibitory fragment. Because genetic variation in the proximal human CHGA promoter predicts autonomic function and blood pressure, we explored how a common genetic variant alters transcription of the gene. METHODS AND RESULTS: Bioinformatic...

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Share to Chromogranin A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoid Enhancer-Binding Factor 1

Share to Promoter Regions, Genetic

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Share to Sympathetic Nervous System

Share to Transcription, Genetic

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 21551321
DOI: 10.1161/CIRCGENETICS.110.957886
PMCID: PMC3319683

Genes

CHGA
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Proteomic analysis yields an unexpected trans-acting point in control of the human sympathochromaffin phenotype.PMID 21551321Read ↗

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