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Article

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells

30 Jun 2008

Abstract excerpt

Dicer, an enzyme involved in microRNA (miRNA) maturation, is required for proper cell differentiation and embryogenesis in mammals. Recent evidence indicates that Dicer and miRNA may also regulate tumorigenesis. To better characterize the role of miRNA in primary cell growth, we generated Dicer-conditional mice. Ablation of Dicer and loss of mature miRNAs in embryonic fibroblasts up-regulated p19(Arf) and p53...

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Identifiers

PMID: 18591425
DOI: 10.1083/jcb.200802105

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