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Article

Functional Redundancy of DICER Cofactors TARBP2 and PRKRA During Murine Embryogenesis Does Not Involve miRNA Biogenesis.

Genetics - 1 Apr 2018

Pullagura Sri Ramulu N, Buaas Bill, Gray Nichelle, Krening Lindsey C, Srivastava Anuj, Braun Robert E

Abstract excerpt

Several in vitro studies have suggested that canonical microRNA (miRNA) biogenesis requires the DICER cofactors TARBP2 and PRKRA for processing of pre-miRNAs to mature miRNAs. To investigate the roles of TARBP2 and PRKRA in miRNA biogenesis in vivo, and to determine possible functional redundancy, we first compared the phenotypes of Tarbp2 and Prkra single and double mutants. In contrast to Dicer -/- embryos,...

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Share to Embryonic Development
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Lethal

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Share to Mice, Knockout

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Source

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Identifiers

PMID: 29467169
DOI: 10.1534/genetics.118.300791
PMCID: PMC5887145

Genes

PRKRA
TARBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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