Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival.

Cancer research - 15 Jul 2010

Arrate Maria Pia, Vincent Tiffaney, Odvody Jessica, Kar Rekha, Jones Stephen N, Eischen Christine M

Abstract excerpt

Many tumor cells express globally reduced levels of microRNAs (miRNA), suggesting that decreased miRNA expression in premalignant cells contributes to their tumorigenic phenotype. In support of this, Dicer, an RNase III-like enzyme that controls the maturation of miRNA, was recently shown to function as a haploinsufficient tumor suppressor in nonhematopoietic cells. Because the Myc oncoprotein, a critical inducer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to DEAD-box RNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoribonucleases

Share to Genes, myc

Share to Genes, p53

Share to Lymphoma, B-Cell

Share to MicroRNAs

Share to Ribonuclease III

Source

Open in PubMed Open full text

Identifiers

PMID: 20587524
DOI: 10.1158/0008-5472.CAN-09-4736
PMCID: PMC2906119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA biogenesis is required for Myc-induced B-cell lymphoma development and survival.PMID 20587524Read ↗

Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer.Semantic proximity Read ↗

c-MYC–miRNA circuitrySemantic proximity Read ↗

Biallelic Dicer1 Mutations in the Gynecologic Tract of Mice Drive Lineage-Specific Development of DICER1 Syndrome-Associated Cancer.Semantic proximity Read ↗

Dicer1 functions as a haploinsufficient tumor suppressor.Semantic proximity Read ↗

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cellsSemantic proximity Read ↗

<i>DICER1</i> syndrome mutations lead to a gain of 3p-miRNA function, HERVH activity and increased metastatic potentialSemantic proximity Read ↗

Canonical and alternate functions of the microRNA biogenesis machinery.Semantic proximity Read ↗

DGCR8-dependent microRNA biogenesis is essential for skin development.Semantic proximity Read ↗

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferationSemantic proximity Read ↗

Dicer-to-Argonaute switch controls biogenesis of oncogenic miRNASemantic proximity Read ↗

Bim is a suppressor of Myc-induced mouse B cell leukemia.Semantic proximity Read ↗

In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.