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MicroRNA biogenesis pathway alterations in aging

1 Jan 2023

Abstract excerpt

Aging is characterized by genomic instability and dysregulation of gene expression. MicroRNAs (miRNAs) are small non-coding RNAs that play a crucial role in post-transcriptional gene regulation. This work explores the impact of dysregulated miRNA biogenesis on the aging process. During aging, alterations in the transcription of primary miRNAs (pri-miRNAs) occur due to genomic changes, DNA damage, and epigenetic...

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PMID: 39698023
DOI: 10.20517/evcna.2023.29

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