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Article

Identification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stress

28 Jun 2013

Abstract excerpt

XFE progeroid syndrome, a disease of accelerated aging caused by deficiency in the DNA repair endonuclease XPF-ERCC1, is modeled by Ercc1 knockout and hypomorphic mice. Tissues and primary cells from these mice senesce prematurely, offering a unique opportunity to identify factors that regulate senescence and aging. We compared microRNA (miRNA) expression in Ercc1-/- primary mouse embryonic fibroblasts (MEFs) and...

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PMID: 23852002
DOI: 10.18632/aging.100571

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