Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DGCR8-dependent microRNA biogenesis is essential for skin development.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jan 2009

Yi Rui, Pasolli H Amalia, Landthaler Markus, Hafner Markus, Ojo Tolulope, Sheridan Robert, Sander Chris, O'Carroll Donal, Stoffel Markus, Tuschl Thomas, Fuchs Elaine

Abstract excerpt

MicroRNAs play important roles in animal development. Numerous conditional knockout (cKO) studies of Dicer have been performed to interrogate the functions of microRNA during mammalian development. However, because Dicer was recently implicated in the biogenesis of endogenous siRNAs in mammals, it raises the question whether the Dicer cKO defects can be attributable to the loss of microRNAs. Previously, we and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DEAD-box RNA Helicases
Share to Endoribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to Proteins

Share to Ribonuclease III

Share to RNA-Binding Proteins

Share to Skin Abnormalities

Source

Open in PubMed Open full text

Identifiers

PMID: 19114655
DOI: 10.1073/pnas.0810766105
PMCID: PMC2626731

Genes

DGCR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DGCR8-dependent microRNA biogenesis is essential for skin development.PMID 19114655Read ↗

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.Semantic proximity Read ↗

Dicer- and BSC-dependent miRNAs during murine anagen developmentSemantic proximity Read ↗

MicroRNA profiling in mid- and late-gestational fetal skin: implication for scarless wound healing.Semantic proximity Read ↗

MicroRNA function is globally suppressed in mouse oocytes and early embryos.Semantic proximity Read ↗

MicroRNAs in skin and wound healingSemantic proximity Read ↗

MicroRNAs in the skin: role in development, homoeostasis and regenerationSemantic proximity Read ↗

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs.Semantic proximity Read ↗

Canonical and alternate functions of the microRNA biogenesis machinery.Semantic proximity Read ↗

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb.Semantic proximity Read ↗

DICER1: mutations, microRNAs and mechanisms.Semantic proximity Read ↗

Biallelic Dicer1 Mutations in the Gynecologic Tract of Mice Drive Lineage-Specific Development of DICER1 Syndrome-Associated Cancer.Semantic proximity Read ↗

A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.