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Article

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.

Nature genetics - 1 Mar 2007

Wang Yangming, Medvid Rostislav, Melton Collin, Jaenisch Rudolf, Blelloch Robert

Abstract excerpt

The molecular controls that govern the differentiation of embryonic stem (ES) cells remain poorly understood. DGCR8 is an RNA-binding protein that assists the RNase III enzyme Drosha in the processing of microRNAs (miRNAs), a subclass of small RNAs. Here we study the role of miRNAs in ES cell dif...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17259983
DOI: 10.1038/ng1969
PMCID: PMC3008549

Genes

DGCR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17259983-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.PMID 17259983Read ↗

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs.Semantic proximity Read ↗

Roles of MicroRNAs in Establishing and Modulating Stem Cell PotentialSemantic proximity Read ↗

Noncanonical function of DGCR8 controls mESC exit from pluripotency.Semantic proximity Read ↗

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A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing.Semantic proximity Read ↗

DGCR8-dependent microRNA biogenesis is essential for skin development.Semantic proximity Read ↗

Dicer1 Is Required for Differentiation of the Mouse Male Germline1Semantic proximity Read ↗

Dicer Is Required for Haploid Male Germ Cell Differentiation in MiceSemantic proximity Read ↗

Genome-wide CRISPR interference screen identifies long non-coding RNA loci required for differentiation and pluripotencySemantic proximity Read ↗

Canonical and alternate functions of the microRNA biogenesis machinery.Semantic proximity Read ↗

<i>DGCR8</i> haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defectsSemantic proximity Read ↗

Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene.Semantic proximity Read ↗

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