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Article

Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation.

World journal of gastroenterology - 7 Jun 2015

Lu Xu-Feng, Zhou Yong-Jie, Zhang Lei, Ji Hong-Jie, Li Li, Shi Yu-Jun, Bu Hong

Abstract excerpt

AIM: To investigate the continuous hepatic histopathological processes which occur in response to the loss of Dicer1. METHODS: We generated a hepatocyte-selective Dicer1 knockout mouse and observed the gradual hepatic histopathological changes in the mutant liver. Immunohistochemistry and Western blotting were performed to detect Dicer1 expression. We performed hematoxylin and eosin staining, Periodic acid-Schiff...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26074697
DOI: 10.3748/wjg.v21.i21.6591
PMCID: PMC4458769

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