Article
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb.
Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2005
Harfe Brian D, McManus Michael T, Mansfield Jennifer H, Hornstein Eran, Tabin Clifford J
Abstract excerpt
The RNaseIII-containing enzyme Dicer is believed to be required for the processing of most, if not all, microRNAs (miRNAs) and for processing long dsRNA into small interfering RNAs. Because the complete loss of Dicer in both zebrafish and mice results in early embryonic lethality, it has been impossible to determine what role, if any, Dicer has in patterning later tissues in the developing vertebrate embryo. To...
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