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Article

Dicer Regulates Differentiation and Viability during Mouse Pancreatic Cancer Initiation

1 May 2014

Abstract excerpt

miRNA levels are altered in pancreatic ductal adenocarcinoma (PDA), the most common and lethal pancreatic malignancy, and intact miRNA processing is essential for lineage specification during pancreatic development. However, the role of miRNA processing in PDA has not been explored. Here we study the role of miRNA biogenesis in PDA development by deleting the miRNA processing enzyme Dicer in a PDA mouse model...

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PMID: 24788257
DOI: 10.1371/journal.pone.0095486

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