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Article

A biological network in Saccharomyces cerevisiae prevents the deleterious effects of endogenous oxidative DNA damage.

Molecular cell - 4 Mar 2005

Huang Meng-Er, Kolodner Richard D

Abstract excerpt

In this study, we used Saccharomyces cerevisiae to identify a biological network that prevents the deleterious effects of endogenous reactive oxygen species. The absence of Tsa1, a key peroxiredoxin, caused increased rates of mutations, chromosomal rearrangements, and recombination. Defects in recombinational DNA double strand break repair, Rad6-mediated postreplicative repair, and DNA damage and replication...

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Identifiers

PMID: 15749020
DOI: 10.1016/j.molcel.2005.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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