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Article

Global genomic instability caused by reduced expression of DNA polymerase ε in yeast.

Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2022

Zhang Ke, Sui Yang, Li Wu-Long, Chen Gen, Wu Xue-Chang, Kokoska Robert J, Petes Thomas D, Zheng Dao-Qiong

Abstract excerpt

SignificanceAlthough most studies of the genetic regulation of genome stability involve an analysis of mutations within the coding sequences of genes required for DNA replication or DNA repair, recent studies in yeast show that reduced levels of wild-type enzymes can also produce a mutator phenotype. By whole-genome sequencing and other methods, we find that reduced levels of the wild-type DNA polymerase ε in...

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Identifiers

PMID: 35290114
DOI: 10.1073/pnas.2119588119
PMCID: PMC8944251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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