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Article

Global analysis of genomic instability caused by DNA replication stress in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2016

Zheng Dao-Qiong, Zhang Ke, Wu Xue-Chang, Mieczkowski Piotr A, Petes Thomas D

Abstract excerpt

DNA replication stress (DRS)-induced genomic instability is an important factor driving cancer development. To understand the mechanisms of DRS-associated genomic instability, we measured the rates of genomic alterations throughout the genome in a yeast strain with lowered expression of the replicative DNA polymerase δ. By a genetic test, we showed that most recombinogenic DNA lesions were introduced during S or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27911848
DOI: 10.1073/pnas.1618129113
PMCID: PMC5167146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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