Article
Damage-induced localized hypermutability.
Cell cycle (Georgetown, Tex.) - 1 Apr 2011
Burch Lauranell H, Yang Yong, Sterling Joan F, Roberts Steven A, Chao Frank G, Xu Hong, Zhang Leilei, Walsh Jesse, Resnick Michael A, Mieczkowski Piotr A, Gordenin Dmitry A
Abstract excerpt
Genome instability continuously presents perils of cancer, genetic disease and death of a cell or an organism. At the same time, it provides for genome plasticity that is essential for development and evolution. We address here the genome instability confined to a small fraction of DNA adjacent to free DNA ends at uncapped telomeres and double-strand breaks. We found that budding yeast cells can tolerate nearly...
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