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Article

Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 27 May 2014

Song Wei, Dominska Margaret, Greenwell Patricia W, Petes Thomas D

Abstract excerpt

In mammalian cells, perturbations in DNA replication result in chromosome breaks in regions termed "fragile sites." Using DNA microarrays, we mapped recombination events and chromosome rearrangements induced by reduced levels of the replicative DNA polymerase-α in the yeast Saccharomyces cerevisi...

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Identifiers

PMID: 24799712
DOI: 10.1073/pnas.1406847111
PMCID: PMC4040566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24799712-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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