Article
STAT3 is required for IL-21-induced secretion of IgE from human naive B cells.
Blood - 1 Sept 2008
Avery Danielle T, Ma Cindy S, Bryant Vanessa L, Santner-Nanan Brigitte, Nanan Ralph, Wong Melanie, Fulcher David A, Cook Matthew C, Tangye Stuart G
Abstract excerpt
The production of immunoglobulin E (IgE) is tightly regulated. This is evidenced by the fact that it comprises less than 0.0001% of serum Ig, and aberrant production causes atopic conditions, including allergy, rhinitis, and anaphylaxis. Interleukin-4 (IL-4) is a well-characterized inducer of IgE by human and murine B cells, whereas interferon-gamma can antagonize this effect. IL-21 has also been recognized for...
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