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Article

IL-21 is a broad negative regulator of IgE class switch recombination in mouse and human B cells

4 Mar 2020

Abstract excerpt

IgE antibodies may elicit potent allergic reactions, and their production is tightly controlled. The tendency to generate IgE has been thought to reflect the balance between type 1 and type 2 cytokines, with the latter promoting IgE. Here, we reevaluated this paradigm by a direct cellular analysis, demonstrating that IgE production was not limited to type 2 immune responses yet was generally constrained in vivo....

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PMID: 32130409
DOI: 10.1084/jem.20190472

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