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Article

Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2015

Wan Chi-Keung, Andraski Allison B, Spolski Rosanne, Li Peng, Kazemian Majid, Oh Jangsuk, Samsel Leigh, Swanson Phillip A, McGavern Dorian B, Sampaio Elizabeth P, Freeman Alexandra F, Milner Joshua D, Holland Steven M, Leonard Warren J

Abstract excerpt

IL-21 is a type I cytokine essential for immune cell differentiation and function. Although IL-21 can activate several STAT family transcription factors, previous studies focused mainly on the role of STAT3 in IL-21 signaling. Here, we investigated the role of STAT1 and show that STAT1 and STAT3 have at least partially opposing roles in IL-21 signaling in CD4(+) T cells. IL-21 induced STAT1 phosphorylation, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26170288
DOI: 10.1073/pnas.1511711112
PMCID: PMC4522759

Genes

STAT1
STAT3
IFNG
TBX21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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