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Article

Interleukin-21 suppresses the differentiation and functions of T helper 2 cells.

Immunology - 1 Apr 2015

Lin Pin-Yi, Jen Hsiao-Yu, Chiang Bor-Luen, Sheu Fuu, Chuang Ya-Hui

Abstract excerpt

T helper type 2 (Th2) cells, which produce interleukin-4 (IL-4), IL-5 and IL-13, control immunity to all forms of allergic inflammatory responses. Interleukin-21 (IL-21) reduces allergic symptoms in murine models and inhibits IL-4-induced IgE secretion by B cells. However, whether or not IL-21 directly affects Th2 cells, which leads to reduced allergic symptoms, is unclear. In this study, we investigated the...

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Source

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Identifiers

PMID: 25351608
DOI: 10.1111/imm.12419
PMCID: PMC4368173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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